Electroencephalography (EEG) Feature Extraction

The research is meant to enable improvement of the management of patients with ESES.

Electrical status epilepticus during slow wave sleep (ESES) is a rare age related disorder, appears in childhood, usually between ages 4 and 9 years, and disappears by puberty. The disorder  is characterized by a combination of multiple type seizures and continuous spike wave discharges during NREM sleep on EEG. The ESES syndrome may present with frequent multiple type seizures,  although  subclinical seizures may occur. 

Inappropriate treatment may lead to persistent  neuropsychological sequela (language capacity, intellectual level, memory, behavior) as well as motor impairment.

The treatment is aimed to control the seizures and the epileptic activity in order to prevent the sequela.

The ESES disorder is usually resistant to multiple antiepileptic drugs. Recurrent sleep EEG study during therapeutic trials is needed for detecting an efficacy of the medications.

Currently it requires monitoring the child during sleep at sleep laboratory or EEG institute using a full set of electrodes which is both an expensive and a tolling procedure. As a result, physicians do not have feedback on the efficiency of the medications which makes the management ineffective.

We attempt to check if we can detect ESES using only frontal electrodes – this can allow a much easier and effective home based monitor that will allow practitioners to better administer the drugs and make the treatment more effective.

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